Best Hormone Replacement Therapy Clinic Software in 2026

Hormone replacement therapy clinics need software that traditional EMRs ignore: lab trending across quarterly panels, compounded hormone dose history with titration schedules, symptom journals that connect to lab results, recurring concierge membership billing, and telehealth for maintenance visits. The insurance-billing EMR ecosystem (Epic, Athena, AdvancedMD) is overkill and poorly fit for cash-pay concierge practices. The generalist EMRs (SimplePractice, Practice Fusion) lack HRT-specific workflows.

This guide compares the five platforms HRT operators most often evaluate in 2026: Cerbo, Kareo (Tebra), Power2Practice, AdvancedMD, and Deelo. Each takes a different angle on what an anti-aging/HRT concierge clinic actually needs.

Deelo takes a fundamentally different approach. Instead of being a specialty EMR, it is an all-in-one business platform where HRT clinics configure Practice for patient records with HRT-specific templates (hormone levels, current doses, titration history, symptom scores), Bookings for telehealth visits, pellet appointments, and lab draws, ESign for HRT consent forms and patient agreements (stored alongside the patient record), Invoicing for recurring concierge membership billing (with 12-month prepay discounts and failed payment dunning), CRM for patient lifecycle tracking (lead, consult, active member, maintenance, graduate), Marketing for educational nurture sequences and patient retention campaigns, and Contacts/Messaging for HIPAA-compliant patient communication between visits.

Lab integration is the one area where specialty EMRs (Cerbo, P2P) still have an edge — they ship with native LabCorp/Quest integrations. Deelo handles this through manual upload or via third-party integration tools. For clinics willing to do this workflow manually or with an integration layer, the cost savings are substantial.

Pricing: $19/seat/month. A 3-clinician HRT clinic runs the whole operation on Deelo for $57/month vs $600-1,200/month for Cerbo or Power2Practice.

Cerbo is the platform most HRT and functional medicine clinics migrate to once they outgrow general EMRs. Built specifically for integrative, anti-aging, and functional medicine practices. Lab trending is best-in-class — results from LabCorp, Quest, DUTCH, and Genova flow into the patient chart with automatic interpretation and comparison to prior panels. Hormone dose tracking, compound order management, and symptom journals are all first-class features.

Pricing: $199-399 per clinician per month depending on modules. The trade-offs: the UI is powerful but has a learning curve, the patient portal is functional but not beautiful, and the marketing/CRM layer is thin — you will pair with Mailchimp or HubSpot for outbound. Best for: established BHRT/HRT clinics with 2+ clinicians and 150+ patients who value deep clinical documentation over generalist features.

Power2Practice (P2P) is a long-standing integrative medicine EHR with strong IV therapy, HRT, and functional medicine workflows. Lab integration, custom hormone protocols, and inventory management (hormone pellets, IV compounds, supplements) are core features. Patient engagement is solid.

Pricing: $175-325 per clinician per month. Compared to Cerbo, P2P is slightly more dated in UI but has deeper inventory and compounding pharmacy workflows. Best for: HRT clinics that also run IV therapy, peptide therapy, or retail supplement sales and need integrated inventory management.

Kareo (now Tebra after the 2022 PatientPop merger) is a strong generalist practice management platform. EHR, billing, telehealth, and patient engagement in one suite. Not built specifically for HRT, but the billing engine is strong and the integrated PatientPop marketing module is useful for clinics investing in local SEO and reputation management.

Pricing: $125-250 per provider per month. HRT-specific workflows (hormone dose tracking, pellet scheduling) require custom templates. Best for: multi-specialty practices where HRT is one of several services, or HRT clinics that want insurance billing for comorbid conditions.

AdvancedMD is a comprehensive enterprise practice management platform. Full EHR, practice management, billing, telehealth, patient engagement, and reporting. Pricing $229-429 per provider per month with implementation fees.

For most HRT clinics, AdvancedMD is overkill. The feature depth is aimed at multi-specialty medical groups. If you are running a 10+ clinician HRT operation or a hospital-affiliated anti-aging clinic, AdvancedMD may scale. For single-location concierge practices, it is too much tool.

Most HRT clinics stack 4-6 tools to cover the full workflow. Typical monthly cost for a 3-clinician concierge practice:

A Deelo subscription ($57-114/month for 3-6 seats) replaces 4-5 of these with one platform. Net monthly savings: $680-1,500. The specialty EMR (Cerbo or P2P) is worth keeping for deep HRT clinical documentation; most of the marketing/CRM/billing/intake layer consolidates nicely on Deelo.

Solo clinician, under 100 patients: Deelo alone can run the clinic. Lab integration is manual but volume is manageable.

Solo to small clinic, 100-300 patients, cash-pay concierge: Cerbo for deep HRT documentation + Deelo for business operations (CRM, marketing, recurring billing, patient messaging). Total cost $250-500/month vs $1,000+/month for traditional stacks.

Multi-clinician (3+), 300+ patients, established concierge practice: Cerbo or Power2Practice as primary EMR + Deelo for business operations. Specialty EMR justified at this scale.

HRT + IV therapy + peptides + aesthetic combo clinic: Power2Practice (deeper inventory management) + Deelo for the business layer.

Insurance-billing HRT practice (cash-pay + some insurance for comorbidities): Kareo/Tebra as primary + Deelo for marketing/CRM.

Pure telehealth HRT (Marek, Maximus-style): Build-your-own on a lightweight EMR + Deelo, with custom workflow for at-scale patient volume.